产品名称:
TPSB2
产品货号:
PLD-218
别名 :
TPS1; TPS2; TPSB1
实验类型 :
IHC-P
反应种属 :
Human
宿主物种 :
Rabbit
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背景
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]
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细胞定位
分泌
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基因 ID
7177
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Swiss Prot
P20231
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别名
TPS1; TPS2; TPSB1
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反应种属
Human
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实验类型
IHC-P
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推荐稀释比
1:200-1:500
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宿主物种
Rabbit
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克隆性
Monoclonal
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同位型
IgG
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纯化方式
Affinity Purification
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偶联物
Un-conjugated
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储存条件
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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