产品名称:
ALK
产品货号:
PLD-290
别名 :
ALK1; CD246; NBLST3
实验类型 :
IHC-P
反应种属 :
Human
宿主物种 :
Rabbit
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背景
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]
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细胞定位
细胞膜
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基因 ID
238
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Swiss Prot
Q9UM73
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别名
ALK1; CD246; NBLST3
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反应种属
Human
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实验类型
IHC-P
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推荐稀释比
1:5000-1:20000
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宿主物种
Rabbit
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克隆性
Monoclonal
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同位型
IgG
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纯化方式
Affinity Purification
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偶联物
Un-conjugated
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储存条件
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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